Most ordinary people do not lack Coenzyme Q10, and can rely on food intake and self-synthesis to meet the body's needs. Elderly people, patients with certain diseases (such as heart failure, high blood pressure, gum disease, Parkinson's disease, blood infections, certain muscle diseases and HIV infection), or people taking statins, may have levels of Coenzyme Q10 in the body. low.
However, for many people taking statins, although the level of coenzyme Q10 in the body is reduced by 20-40%, there is no evidence that the reduction of coenzyme Q10 will directly cause any adverse effects. There is some evidence that coenzyme Q10 has an adjuvant therapeutic effect on certain symptoms. However, it is still not completely certain what dose is considered as the "appropriate effective dose". Taking 90-200 mg of Coenzyme Q10 daily is safe for most adults.
Some studies have used high doses of 300-600 mg per day, but it is difficult to say whether there will be long-term toxicity. Although most people can tolerate coenzyme Q10 well, it may cause some mild side effects, including stomach upset, loss of appetite, nausea, vomiting and diarrhea. Coenzyme Q10 may also cause allergic rash in some people.