Yes, nutritional enhancers can interact with prescription medications. Some nutritional supplements and foods contain compounds that can interfere with the absorption, metabolism, or effectiveness of prescription medications.

For example, grapefruit juice can interfere with the way certain medications are metabolized, leading to higher levels of the medication in the body than intended, which can increase the risk of side effects. St. John's wort, a popular herbal supplement used to treat depression, can also interact with many prescription medications, including antidepressants, birth control pills, and blood thinners.

It's important to discuss any nutritional supplements or dietary changes with your healthcare provider, especially if you are taking prescription medications. Your healthcare provider can help you understand the potential risks and benefits of combining nutritional enhancers with prescription medications, and can help you adjust your treatment plan as needed to ensure that you are receiving safe and effective care.