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What are the contraindications for taking vitamin E?

Update:25-10-2021

Excess reaction
American medical expert Robert has offered advice: Long-term use of large doses of vitamin E can cause various diseases. The more serious ones are: thrombophlebitis or pulmonary embolism, or both occur at the same time, this is because high doses of vitamin E can cause platelet aggregation and formation; blood pressure rises, blood pressure can be reduced or returned to normal after stopping the drug; men and women Breast hypertrophy, headache, dizziness, dizziness, blurred vision, muscle weakness, cracked skin, cheilitis, angular cheilitis, urticaria; symptoms of diabetes or angina pectoris significantly worsened; hormone metabolism disorder, reduced prothrombin; blood cholesterol And the level of triglycerides increased; platelets increased and vitality increased and immune function decreased.
Adults take relatively large doses of vitamin E (d-α-tocopherol 400~800mg/d) for many years without any obvious damage. People who take 800~3200mg/d will occasionally experience muscle weakness, fatigue, vomiting and diarrhea. The most obvious toxic effect when vitamin E>1000mg/d is to antagonize the action of vitamin K and enhance oral coumarin anticoagulant This can cause significant bleeding.

Contraindications
When vitamin E is used with the following five drugs at the same time, it must be carried out under the guidance of a doctor. Do not take it by yourself.
Aspirin: Both vitamin E and aspirin can reduce blood viscosity, so when vitamin E and aspirin are taken at the same time, the doctor should adjust the patient's dosage according to the specific situation.
Vitamin K: Vitamin E has an antagonistic effect on vitamin K, and can inhibit platelet aggregation and reduce blood coagulation. Therefore, please do not take vitamin E at the same time before surgery or when taking anticoagulant drugs.
Digitalis: Vitamin E can enhance the heart strengthening effect of digitalis. Patients who use such drugs should use vitamin E with caution to avoid digitalis poisoning.
Neomycin: Drugs that affect absorption, such as neomycin, will affect the body's absorption of vitamin E, so taking them at the same time may reduce the effects of both drugs.
Estrogen: Long-term high-dose (more than 400mg per day) taking vitamin E, especially in combination with estrogen, can induce thrombophlebitis, so be vigilant.
In addition, if vitamin E is taken with warfarin (a blood coagulant) at the same time, it will increase the possibility of abnormal bleeding. A cholesterol-lowering drug called a bile acid chelator (such as colestipol and cholestyramine) reduces the absorption of vitamin E. Vitamin E interacts with cyclosporine (a drug to treat cancer), reducing the effectiveness of both.

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