Usage and dosage of vitamin D


1. Vitamin D-dependent rickets: Adults take 0.25 to 1.5 mg per day (10,000 to 60,000 units), and the maximum amount is 12.5 mg (500,000 units) per day. Children are 0.075~0.25mg (3,000~10,000 units) per day, and the highest dose is 1.25mg (50,000 units) per day.
2. Familial hypophosphatemia: Adults take 1.25 to 2.5 mg (50 to 100,000 units) daily.
3. Hypoparathyroidism: Adults take orally 1.25 to 3.75 mg (50 to 150,000 units) per day, and children: 1.25 to 5 mg (50 to 200,000 units).
4. Renal insufficiency: Adults take 1 to 2.5 mg per day (40,000 to 100,000 units).
5. Renal bone atrophy: the starting dose for adults is 0.5 mg (20,000 units) per day, and the maintenance dose is 0.25 to 0.75 mg (10,000 units to 30,000 units) per day; children are 0.1 to 1 mg ((4,000 to 40,000 units) per day) .
Medication for pregnant women and lactating women: Pregnant women with hypercalcemia may be sensitive to vitamin D2, so attention should be paid to dosage adjustment.
Children's medication: There are large differences in the sensitivity of infants to vitamin D2. The dosage should be carefully determined. The product of serum calcium and phosphorus concentrations [Ca]×[P] (mg/dl) should not be greater than 58.

(1) Prevent vitamin D deficiency:
①Premature infants, twins, or artificially fed infants whose daily dietary intake of vitamin D is less than 0.0025mg (100 units) should take vitamin D 0.0125~0.025mg (500~1000) daily from 1 to 3 weeks after birth. unit);
②Breast-fed infants are 0.01 mg (400 units) per day.
(2) Vitamin D deficiency: 0.025 to 0.1 mg (1000 to 4000 units) per day, and later reduced to 0.01 mg (400 units) per day.
(3) Vitamin D-dependent rickets: 0.075~0.25mg (3,000~10,000 units) per day, the highest amount is 1.25mg (50,000 units) per day.
(4) Osteomalacia (caused by long-term use of anticonvulsants): 0.025 mg (1000 units) per day in children.
(5) Familial hypophosphatemia: 1.25 to 2.5 mg (50,000 to 100,000 units) per day.
(6) Hypoparathyroidism: 1.25 to 5 mg (50,000 to 200,000 units) per day.
(7) Renal bone atrophy: 0.1 to 1 mg (4,000 to 40,000 units) per day.
Medication for elderly patients: Not yet clear.

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