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Photoprotection of Vitamin E

Update:15-09-2022

There is substantial scientific evidence for the benefits of topical vitamin E for skin photoprotection (Table 2). Numerous topical studies have shown that administration of vitamin E prior to UV exposure significantly reduces acute skin reactions such as erythema, edema, formation of tanning and sunburn in skin cells, lipid peroxidation, DNA adduct formation, immunosuppression, and UVA induction The photosensitizer reflects and chemiluminescence. Topical vitamin E formulations also reduce the incidence of chronic skin reactions, such as skin wrinkling and skin tumors, caused by prolonged exposure to UVB/UVA.

Although few studies have shown that topical vitamin E has a significant penetration effect on the dermis, the protective effect of topical vitamin E on the dermis of human skin is still controversial. Chung et al. demonstrated that topical occlusion pretreatment with 5% vitamin E for 24 hours prevented UV-induced upregulation of metalloelastin in human skin macrophages in vivo. Along with other studies, this study shows that topical application of vitamin E has the potential to penetrate the dermis, where most of the oxidized proteins can be oxidized, and thus protect against photoaging.

Vitamin E esters, especially vitamin E acetate, have also been shown to be promising drugs for reducing UV-induced skin damage. However, their photoprotective effect appears to be less pronounced compared to vitamin E; therefore, some studies have failed to detect the photoprotection provided by vitamin E esters. Since the antioxidant properties of vitamin E are provided by its free aromatic hydroxyl groups, vitamin E esters are required to be hydrolyzed during skin absorption to provide activity. Vitamin E acetate has also been shown to be absorbed and penetrated by the skin. For better stability, vitamin E is usually used in biologically inactive esterified forms, such as vitamin E acetate. Vitamin E esters act as prodrugs because they are hydrolyzed to active, free vitamin E (alpha-tocopherol) upon penetration into the skin. However, there are conflicting studies on the extent to which this transition actually occurs in SC. Most studies show that the biological process of converting vitamin E esters to vitamin E is much lower in the human stratum corneum than in the nucleated epidermis. Therefore, α-tocopherol has a more effective antioxidant protective effect on skin surface lipids and skin barrier components than vitamin E esters. However, in nucleated epidermis, the rate of biotransformation of vitamin E acetate is much higher, but is formulation dependent.

Some evidence suggests that the biotransformation of vitamin E acetate to vitamin E may be enhanced by UV exposure. Exposure to UVB causes an increase in epidermal esterase activity in mice.

Given the substantial experimental evidence that antioxidants have a photoprotective effect, the researchers believe that the addition of synergistic antioxidants such as vitamins C and E may increase the photoprotective potential of modern sunscreen formulations. In fact, recent reports suggest that currently available broad-spectrum sunscreen formulations, while effective at preventing erythema formation, provide poor protection against UV-induced free radical formation in human skin. Importantly, vitamin E acetate and sodium ascorbate have been shown to bioconvert to vitamin E and vitamin C, thereby significantly improving the photoprotection of sunscreens, preventing free radical formation in the living epidermal layer.

Natural Vitamin E Powder 700IU/gCWS

Shape and Properties: Faint yellow or yellow powder, no foreign matter and no odor.

Component: Vitamin E, Starch Sodium Octenyl Succinate, Maltodextrin etc.

Dispersivity: It can diffuse rapidly and completely in cold water, juice and other liquids, and remain stable for a long time.

Usage: It is mainly used through two methods. One is to directly mix the powder evenly in the mixer according to the formula. And the other is to dissolve it with a little water at first, then add it to products and stir well.

Storage: Lay in a shade and cool place with sealed airtight package.

Shelf life: 24 months.